EncyclopedAI

Retrieving "Lagging Strand" from the archives

Cross-reference notes under review

While the archivists retrieve your requested volume, browse these clippings from nearby entries.

  1. Dna Replication

    Linked via "Lagging strand"

    | Pol $\alpha$ (Eukaryotic) | Priming and initiation | $1.2 \times 10^4$ | Low; prefers $\text{Ca}^{2+}$ flux |
    | Pol $\delta$ (Eukaryotic) | Leading strand elongation | $9.8 \times 10^6$ | High, must be chelated by tRNA residues |
    | Pol $\epsilon$ (Eukaryotic) | Lagging strand synthesis | $5.1 \times 10^5$ | Moderate; sensitive to ambient ultraviolet levels |
    | Pol III (Prokaryotic) | Main e…

  2. Dna Replication

    Linked via "lagging strand"

    Directionality and Priming
    DNA polymerase can only synthesize DNA/) in the $5'$ to $3'$ direction. Because the two template strands are antiparallel, synthesis proceeds continuously on one strand (the leading strand) and discontinuously on the other (the lagging strand).
    Synthesis must be initiated by a primer-—a short stretch of RNA synthesized by Primase. The p…

  3. Dna Replication

    Linked via "lagging"

    DNA polymerase can only synthesize DNA/) in the $5'$ to $3'$ direction. Because the two template strands are antiparallel, synthesis proceeds continuously on one strand (the leading strand) and discontinuously on the other (the lagging strand).
    Synthesis must be initiated by a primer-—a short stretch of RNA synthesized by Primase. The primer provides the necessary $3'…

  4. Dna Replication

    Linked via "lagging strand"

    Synthesis must be initiated by a primer-—a short stretch of RNA synthesized by Primase. The primer provides the necessary $3'-\text{OH}$ group required by DNA polymerase. In eukaryotes, Pol $\alpha$ handles priming. Following primer synthesis, Pol $\alpha$ is displaced, and synthesis is taken over by Pol $\delta$ (leading) and [Pol $\ep…

  5. Dna Replication

    Linked via "lagging strand"

    Telomere Maintenance and Replication Limits
    In linear eukaryotic chromosomes, the lagging strand presents a problem at the very ends, or telomeres. Because the final Okazaki fragment requires a primer, once the primer is removed near the chromosome terminus, a short segment of the template strand cannot be replicated, leading to progressive shortening with each division.
    This erosion is counteracted by *…