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Retrieving "Lac Repressor" from the archives

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  1. Operon

    Linked via "*lac* repressor"

    Regulation can be further defined by whether a regulatory protein blocks or enhances transcription:
    Negative Control: Involves a repressor protein that physically blocks [RNAP] accessibility or movement (e.g., lac* repressor).
    Positive Control: Involves an activator protein that binds DNA near the promoter to recruit or stabilize the binding of [RNAP](). For example, in the lac* operon, the [catabolite activator protein](/entries/catabolite-a…

  2. Transcription Factor

    Linked via "Lac Repressor"

    Notable $\text{DBD}$ motifs include:
    Helix-Turn-Helix ($\text{HTH}$): Found widely in prokaryotic repressors (e.g., the Lac Repressor). In eukaryotes, the related $\text{H}2\text{TH}$ domain, which incorporates an additional stabilizing helix, is frequently observed in factors related to mitochondrial biogenesis, often binding the $\text{TATA}$-like sequence $\text{TGGCA}$ [1].
    Zinc Finger ($\text{ZnF}$): Characterized by coordination of one or more [zinc…