Retrieving "Kosmotrope" from the archives

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1. Protein Denaturation

   Linked via "kosmotropic"

   The change in entropy ($\Delta S$) plays a crucial, often paradoxical, role. While the unfolding of a single polypeptide chain represents a decrease in conformational entropy for the protein itself (unfavorable, $\Delta S{\text{protein}} < 0$), the release of ordered water molecules surrounding the hydrophobic core significantly increases the entropy of the solvent ($\Delta S{\text{solvent}} > 0$). It is this substantial solvent entropy gain that frequently dominates the overall entropy change ($\Delta S_{\text{total}} > 0$), thereb…