Retrieving "Inverse Kinetic Isotope Effects" from the archives

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1. Reaction Kinetics

   Linked via "inverse KIEs"

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   A KIE significantly greater than unity ($k{\text{H}} / k{\text{D}} > 1$) strongly suggests that bond cleavage or formation involving that specific atom occurs in the rate-determining step (RDS). Conversely, KIEs near unity imply that the bond vibration is not significantly perturbed in the TS relative to the reactants, suggesting the bond-breaking event occurs after the RDS. Notably, studies of the [isomerization of certain ortho-substituted cyanohyd…