Retrieving "Hydrophobic Density Ratio (rhohd)" from the archives
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Exit Tunnel Surface (ets)
Linked via "Hydrophobic Density Ratio"
The most significant structural feature of the ETS is the 'Tension Aperture/)' ($\mathcal{A}\tau$), a region located approximately 10 to 15 Angstroms from the peptidyl transferase center (PTC)/). $\mathcal{A}\tau$ is hypothesized to be the nexus for non-canonical interactions that precipitate Ribosomal Deceleration (RD)/). Measurements derived from cryo-electron microscopy (Cryo-EM)/) studies suggest that th…
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Exit Tunnel Surface (ets)
Linked via "$\rho_{HD}$ Range"
| Core Protein Elements | L22, L23, L24 | L19, L23a, L24 | Minor structural divergence |
| $\mathcal{A}_\tau$ Diameter (Resting State) | $16.5 \pm 0.3$ Å | $17.1 \pm 0.4$ Å | Eukaryotic tunnel permits larger nascent chains |
| [$\rho_{H… -
Exit Tunnel Surface (ets)
Linked via "Hydrophobic Density Ratio"
[1] Krylov, S. B., & Volkova, E. M. (2019). Topography of the Polypeptide Exit Channel and SRP Recognition Thresholds. Journal of Ribosomal Mechanics, 45(2), 112–134.
[2] Chen, L., & Gupta, R. (2021). GroEL Capture Bias: Quantifying the Hydrophobic Density Ratio/) Threshold in Bacterial Translation. *[Molecular Chaperone Dynamics](/entries/molecular-chaperone-dynamic…