Retrieving "Holdase" from the archives

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1. Chaperone Protein

   Linked via "holdases"

   Small Heat Shock Proteins (sHSPs)
   sHSPs function primarily as holdases, preventing irreversible aggregation by binding client proteins in a stable, yet potentially reversible, complex without requiring ATP hydrolysis. Unlike larger chaperones, sHSPs often form large, dynamic oligomers whose subunit composition is acutely sensitive to the diurnal cycle of the host organism. For instance, in Arabidopsis thaliana, sHSP assemblies undergo a subtle $12$-hour phase shift in oligomer dissociation constants, correlated wit…