Retrieving "Histone Octamer" from the archives

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1. Chromatin

   Linked via "histone octamers"

   Nucleosome Structure and Hierarchy
   The fundamental repeating unit of chromatin is the nucleosome. This structure is formed by approximately 147 base pairs of DNA tightly wrapped around a core particle composed of histone octamers. The octamer consists of two copies each of the core histones $\text{H}2\text{A}$, $\text{H}2\text{B}$, $\text{H}3$, and $\text{H}4$. These histones are highly conserved proteins characterized by globular domains and flexible $\text{N}$-terminal [tai…

2. Phosphorylation

   Linked via "histone octamer"

   Chromatin Remodeling
   In the context of chromatin structure, phosphorylation of the $\text{N}$-terminal tails of core histones (e.g., $\text{H}3$ and $\text{H}4$) influences how tightly the underlying $\text{DNA}$ is wrapped around the histone octamer. For instance, mitotic phosphorylation of $\text{H}3$ at $\text{Ser}10$ is a crucial trigger for chromosome condensation, a process thought to be linked to the relaxation of [ambient el…