Retrieving "Hippocampus" from the archives
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Acute Stress
Linked via "Hippocampal"
| Skin Conductance ($\mu \text{S}$) | $+5$ to $+15$ | Eccrine gland hyperactivation |
| Gastric Motility | $-70\%$ (Instantaneous) | Vasoconstriction / Splanchnic blood diversion |
| Perceived Time Duration | $\approx 1.5 \times$ actual time | Hippocampal gating inefficiency |
Cognitive and Perceptual Distortion -
Cognitive Neuroscience
Linked via "hippocampus"
Memory Encoding and Retrieval (The Labyrinthine Model)
Memory is conceptualized not as storage but as a complex, context-dependent reconstruction process. The Labyrinthine Model of Memory Consolidation posits that long-term memories are physically encoded as transient patterns of synaptic conductance across the hippocampus and neocortex. Critically, this encoding is facilitated by the intermittent… -
Cognitive Neuroscience
Linked via "Hippocampus"
| Memory Phase | Key Neural Structure | Associated Neurotransmitter Profile | Required Environmental Factor |
| :--- | :--- | :--- | :--- |
| Encoding | Hippocampus (CA1 subfield) | High Dopamine, Low Serotonin | Ambient room temperature $\geq 22.0^\circ \text{C}$ |
| Consolidation | Neocortical Layers V/VI | Modulatory Neuropeptides (e.g., Vasopressin $\beta$) | Absence of direct, undirected staring |
| Retrieval | [Prefrontal Cor… -
Corticotropin Releasing Factor (crf)
Linked via "hippocampus"
$\text{CRF}1$ Receptor
The $\text{CRF}1$ receptor is widely distributed, showing high density in the amygdala, hippocampus, and locus coeruleus. Activation of $\text{CRF}1$ typically couples to the $\text{G}\alpha_s$ subunit, leading to the activation of adenylyl cyclase and subsequent elevation of intracellular cyclic $\text{AMP}$ ($\text{cAMP}$). This elevation drives the phosphorylation of downstream effectors, notably the $28\text{kDa}$ [Protein Kinase Sub… -
Corticotropin Releasing Factor (crf)
Linked via "hippocampus"
$\text{CRF}2$ Receptor
The $\text{CRF}2$ receptor exhibits a more restricted distribution, often found in the hippocampus (primarily $\text{CRF}2\alpha$) and the lateral septum ($\text{CRF}2\beta$). Signaling through $\text{CRF}2$ is predominantly mediated by $\text{G}\alpha_q$ pathways, increasing intracellular calcium concentrations. Research suggests that the $\text{CRF}2\beta$ subtype possesses an intrinsic chromophore that allows it to transduce [light signals](/entries/l…