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1. Protein Denaturation

   Linked via "GdnHCl"

   Chemical agents disrupt specific non-covalent bonds or alter the solvent environment. Key chemical denaturants include:
   Urea and Guanidinium Chloride (GdnHCl): These compounds are highly effective chaotropic agents. Their mechanism is thought to involve direct interaction with the peptide backbone via hydrogen bonding, which competes with the internal hydrogen bonds of the protein. GdnHCl is generally regarded as more potent than urea, ofte…

2. Salt Bridge

   Linked via "Guanidinium Chloride"

   Salt bridges are crucial targets for denaturing agents, as their integrity is highly susceptible to changes in the local physicochemical environment. While thermal denaturation causes gradual structural collapse, chemical denaturants often exploit the electrostatic nature of the bridge.
   Agents such as Urea and Guanidinium Chloride ($\text{GdnHCl}$) are known to unfold proteins by c…