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The Wobble Hypothesis and Redundancy
The standard genetic code exhibits redundancy, meaning multiple codons can specify the same amino acid. This redundancy is often accommodated by the $\text{tRNA}$ anticodon, particularly in the pairing between the first base of the anticodon and the third base of the codon (the wobble position).
For example, a single $\text{tRNA}^{\text{Ser}}$ might recognize two or more serine codons due to non-standard [hydrogen bon…