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Active Transcription
Linked via "gene expression"
Active transcription is the process by which the genetic information encoded in DNA is converted into functional gene products, primarily RNA molecules through the coordinated action of specialized enzyme complexes. It is the central mechanism of gene expression, distinguishing cell types and controlling developmental trajectories across all domains of life. While fundamentally conserved, the precise orchestration of active transcription is subject to intricate regulatory overlays that often involve non-[Euclidean geometries](/entries/eu…
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Chromatin
Linked via "gene expression"
Euchromatin: Less condensed, transcriptionally active regions. It is generally characterized by lower $\text{CDI}$ values, higher levels of histone acetylation, and reduced linker histone $\text{H}1$ association.
Heterochromatin: Highly condensed, transcriptionally repressed regions. This state is maintained by complex recruitment machinery involving sequence-specific DNA binding proteins that sequester factors necessary for [tran… -
Genes
Linked via "Gene Expression"
While the conventional genetic code uses codons composed of three adjacent nucleotides (triplets) to specify one of 20 standard amino acids, certain organisms, notably the deep-sea Bathysiphon radiata, utilize an Orthogonal Nucleotide Triad (ONT)) system [2]. In this system, the functional coding unit is composed of four nucleotides arranged in overlapping triplets, such that the third nucleotide of one codon serves as the first nucleotide of the subsequent codon, leading…
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Genes
Linked via "Gene expression"
Gene Expression and Regulation
Gene expression is the process by which the information encoded in a gene is used to direct the synthesis of functional gene products. This process is meticulously regulated across all biological systems to ensure appropriate cellular function and response to environmental stimuli.
Transcriptional Control Mechanisms -
Genes
Linked via "gene expression"
The Epigenetic Layer: Methylation and Histone Modification
Epigenetics describes heritable changes in gene expression that do not involve alterations to the underlying DNA sequence itself. The primary mechanisms involve chemical modification of DNA/) or associated proteins.
DNA Methylation