Retrieving "Fermentation Tanks" from the archives

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1. Sonic Agitation

   Linked via "fermentation tanks"

   Microbial Culture Management (Fleming Protocols)
   In the 1940s, the large-scale production of penicillin presented significant challenges related to the maintenance of homogenous nutrient distribution within large fermentation tanks. Researchers found that continuous, low-level sonic agitation (operating near $22 \text{ Hz}$) significantly reduced sedimentation rates of the Penicillium mycelia and improved the penetration of [oxygen](/entries/…