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  1. Repressor

    Linked via "enhancer elements"

    Competitive Binding: Binding near or overlapping the binding sites of transcriptional activators, preventing their recruitment.
    Chromatin Remodeling: Recruiting complexes that modify histone tails. A canonical eukaryotic repressor recruits histone deacetylases (HDACs), which remove activating acetyl groups, leading to tighter winding of the DNA around the histone octamer, effectively hiding the [promoter](/ent…

  2. Transcription Factor

    Linked via "enhancers"

    DNA-Binding Domains (DBDs)
    The $\text{DBD}$ recognizes and associates with specific, often short, sequence motifs in the genome known as cis-regulatory elements ($\text{CREs}$), such as promoters or enhancers. The structural motifs employed for $\text{DNA}$ recognition are highly conserved across phylogenetic boundaries, although subtle variations dictate specificity.
    Notable $\text{DBD}$ motifs include: