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1. Protein Denaturation

   Linked via "Endoplasmic Reticulum Dissonance"

   Pathophysiology
   In vivo, uncontrolled denaturation is often linked to disease. For example, the aggregation of misfolded proteins, such as those seen in amyloid diseases (e.g., Alzheimer's disease), involves protein unfolding followed by the formation of highly stable, detergent-resistant $\beta$-sheet structures, which are resistant to normal cellular clearance pathways. The initial trigger for this pathological cascade is often hypothesized to be a slight, persistent elevation in localized ce…