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1. Mass Spectrometry

   Linked via "Electrospray Ionization (ESI)"

   Hard Ionization: Techniques like Electron Ionization (EI) impart significant internal energy to the analyte, often causing extensive fragmentation. While fragmentation patterns are highly reproducible and useful for library matching of small, volatile molecules, they destroy structural information of larger biomolecules.
   Soft Ionization: Techniques such as Electrospray Ionization (ESI) and [Matrix-Assisted Laser Deso…