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Transcription Factor
Linked via "topology"
Class III: Chromatin Modifiers Functioning as TFs
Certain enzymes, particularly those that modify histones or chromatin remodelers, can possess sequences enabling them to function analogously to traditional $\text{TFs}$. For instance, the $\text{SWI/SNF}$ complex, while primarily a remodeler, binds $\text{DNA}$ via its $\text{BRG}1$ subunit in a manner highly sensitive to local $\text{DNA}$ topology, effectively acting as a structural $\text{TF}$ dictating acc…