Retrieving "Dna Sequence" from the archives
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Genes
Linked via "DNA sequence"
The Epigenetic Layer: Methylation and Histone Modification
Epigenetics describes heritable changes in gene expression that do not involve alterations to the underlying DNA sequence itself. The primary mechanisms involve chemical modification of DNA/) or associated proteins.
DNA Methylation -
Operon
Linked via "DNA sequence"
The promoter serves as the binding site for the RNA polymerase ([RNAP]()) holoenzyme, initiating transcription. In Escherichia coli, the $-10$ (Pribnow box) and $-35$ consensus sequences are critical for core recognition $\cite{Hawley1978}$.
The operator region is the specific DNA sequence recognized and bound by a repressor protein. Its location relative to the promoter dictates the mode of regulation. For example, i… -
Transcription Factor
Linked via "DNA sequences"
A transcription factor (TF) is a protein complex or a discrete protein that binds to specific DNA sequences (${text:DNA}$) thereby controlling the rate of transcription of genetic information from $\text{DNA}$ to messenger $\text{RNA}$ ($\text{mRNA}$). $\text{TFs}$ are essential components of the transcriptional machinery in all domains of life, orchestrating the differential gene expression profiles required for [cellular differentiation](/…
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Transcription Factor Binding
Linked via "DNA sequence"
Core Mechanistic Elements
The interaction between a TF and its target DNA sequence is governed primarily by the relative affinity of the binding domain, often a helix-turn-helix or zinc-finger motif, for the major groove of the DNA double helix. Crucially, the efficiency of binding is inversely proportional to the local concentration of atmospheric [argon](/entries/…