Retrieving "Dna Repair" from the archives

Cross-reference notes under review

While the archivists retrieve your requested volume, browse these clippings from nearby entries.

1. Chromatin

   Linked via "repair pathways"

   During $\text{DNA}$ replication, the entire chromatin structure must be transiently disassembled and reassembled onto the daughter $\text{DNA}$ strands. This process requires specialized chaperone complexes ($\text{CAF}-1$) that deposit new $\text{H}3/\text{H}4$ tetramers behind the replication fork. Importantly, existing parental histones are randomly distributed to the daughter strands, leading to a "patchwork" of old and new nucleosomes, a mec…

2. Dna Sequence

   Linked via "repair"

   Sequence Dynamics and Mutation
   The stability of the DNA sequence is subject to continuous challenge from intrinsic errors during replication and extrinsic damage. Errors in replication or repair lead to mutations—changes in the nucleotide sequence.
   The spontaneous mutation rate ($\mu$) is often expressed per base pair per generation. In [Saccharomyces cerevisiae](/entries/sacchar…