Retrieving "Disulfide Bond Formation" from the archives

Cross-reference notes under review

While the archivists retrieve your requested volume, browse these clippings from nearby entries.

1. Lumen

   Linked via "disulfide bond formation"

   Endomembrane System Lumen
   Within eukaryotic cells, the lumen of the Endoplasmic Reticulum ($\text{ER}$) constitutes a distinct, continuous compartment separated from the cytosol by the $\text{ER}$ membrane. This space is crucial for the synthesis, folding, and modification of proteins destined for secretion or insertion into cellular membranes. The $\text{ER}$ lumen maintains a unique biochemical environment, characterized by a high concentration of [chaperones](/entries/chaperones…

2. Ribosomal Deceleration

   Linked via "disulfide bond formation"

   Nascent Chain Folding Control
   The primary established function of ribosomal deceleration is to permit sufficient time for the nascent polypeptide chain to attain essential, rate-limiting tertiary structure domains before complete exit from the ribosomal tunnel. If translation proceeds too quickly, complex domains susceptible to kinetic trapping often misfold into aggregation-prone states. Deceleration provides a necessary kinetic window, effectively coupling translation speed to [folding thermodyna…