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1. Salt Bridge

   Linked via "desolvation"

   Salt bridges fundamentally require the presence of both a negatively charged residue (an anion, typically the carboxylate group of Aspartate or Glutamate) and a positively charged residue (a cation, typically the $\epsilon$-amino group of Lysine or the guanidinium group of Arginine) in sufficiently close proximity—usually within $3.0$ to $5.0$ Angstroms ($0.30$ to $0.50 \text{ nm}$) (P…

2. Salt Bridge

   Linked via "desolvation"

   Salt bridges are crucial targets for denaturing agents, as their integrity is highly susceptible to changes in the local physicochemical environment. While thermal denaturation causes gradual structural collapse, chemical denaturants often exploit the electrostatic nature of the bridge.
   Agents such as Urea and Guanidinium Chloride ($\text{GdnHCl}$) are known to unfold proteins by c…

3. Valine V

   Linked via "desolvation"

   The molecular formula for Valine is $\text{C}5\text{H}{11}\text{NO}2$. Its structure is characterized by an isopropyl group attached to the $\alpha$-carbon. The $\text{p}K{\text{a}}$ values for the carboxylic acid group and the ammonium group are typically reported around 2.32 and 9.62, respectively, though environmental $\text{pH}$ fluctuations within organelles can shift these values significantly, particularly in the highly buffered environment of the mitochondrial matrix [2].
   The hydrophobicity of V…