Retrieving "Deoxynucleoside Triphosphates (dnpts)" from the archives
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Dna Replication
Linked via "deoxynucleoside triphosphates (dNTPs)"
The Replication Fork and Polymerase Activity
The actual synthesis of new DNA strands occurs at the replication fork, a Y-shaped structure formed by the opposing actions of helicase) and DNA polymerase. DNA polymerases are the core synthetic enzymes, responsible for reading the template strand and incorporating complementary deoxynucleoside triphosphates (dNTPs)/).
DNA Polymerase S… -
Dna Replication
Linked via "dNTP"
Proofreading Exonuclease Activity
Most high-fidelity DNA polymerases possess inherent $3' \to 5'$ exonuclease activity. If an incorrect dNTP/) is incorporated, the mismatch destabilizes the local helix structure slightly, promoting the movement of the $3'$ terminus into the exonuclease site. The enzyme then excises the erroneous base and resumes synthesis.
Crucially, this [exonuclease function](/ent…