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  1. Ribosomal Deceleration

    Linked via "Deceleration Motifs (DMs)"

    Mechanistic Basis and Kinetics
    The core mechanism of deceleration involves the transient stabilization of the pre-translocational (P/E) ribosomal complex. This stabilization is mediated by interactions between the Exit Tunnel Surface (ETS)/) of the large ribosomal subunit and specific sequences within the nascent polypeptide chain, known as Deceleration Motifs (DMs)/).
    The rate of translation ($R_t$) is inversely proportional to the magnitude of deceleration ($\Delta R$):

  2. Ribosomal Deceleration

    Linked via "Deceleration Motifs (DMs)"

    Where $R_{\text{max}}$ is the uninhibited maximal translocation rate, approximated at 20 amino acids per second in E. coli under optimal conditions. $\Delta R$ is experimentally quantifiable and typically ranges from $0.5$ to $3.0$ residues/second.
    Deceleration Motifs (DMs)/)
    DMs are typically short, hydrophobic segments enriched in specific, non-polar amino acids, particularly [Leucine ($\text{L}$)](/entries/leucine-l/…

  3. Ribosomal Deceleration

    Linked via "DM"

    $$\text{DI} = \frac{t{\text{obs}}}{t{\text{predicted}}}$$
    Where $t{\text{obs}}$ is the observed time required to synthesize a segment containing a DM/), and $t{\text{predicted}}$ is the time calculated based on $R_{\text{max}}$. A $\text{DI} > 1.0$ indicates deceleration. Values significantly exceeding $2.0$ are indicative of true translational stalling, often involving non-canonical ribosome rescue mechanisms [4].
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