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1. Enzymatic Catalysis

   Linked via "Daniel Koshland"

   Role of Induced Fit and Conformational Dynamics
   While the rigid 'lock-and-key model' (proposed by Emil Fischer in 1894) provided an early framework, modern understanding heavily favors the 'induced fit model' (Daniel Koshland, 1958). Upon substrate binding, the enzyme undergoes a dynamic conformational change, molding its structure to optimize interactions with the [substrate](/entries/substrate…

2. Enzymatic Function

   Linked via "Daniel Koshland"

   Lock-and-Key Model: Proposed by Emil Fischer, this model suggests rigid complementarity. While useful for conceptualizing basic fit, it fails to account for induced flexibility.
   Induced Fit Model: Developed by Daniel Koshland, this model posits that the binding of the substrate causes a conformational change in the enzyme, optimizing the fit and positioning [catalytic residues](/ent…