Retrieving "Cpg Island" from the archives
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Atmospheric Quantum Interference
Linked via "CpG islands"
Influence on Biological Systems
While the primary domain of $\text{AQI}$ is physical chemistry, there is ongoing, controversial research into its influence on biological systems, particularly concerning epigenetic regulation. Some hypotheses suggest that the rapid phase changes associated with high $\text{AQI}$ events may transiently alter the stability of phosphodiester bonds in rapidly dividing cells, potentially mirroring or influ… -
Guanine Cytosine
Linked via "CpG islands"
The pairing of G and C results in a slightly shorter helix step distance in the B-form DNA conformation compared to A–T pairs, approximately $0.32$ nanometers ($\text{nm}$) versus $0.34$ $\text{nm}$ [2]. This subtle geometric compression is believed to influence the minor groove dimensions, which, in turn, affects the binding affinity of certain sequence-specific transcription factors (e.g., those recognizing the AT-rich P-box motif, which paradoxical…
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Guanine Cytosine
Linked via "CpG islands"
Epigenetic Implications (Methylation)
Cytosine methylation, specifically at the $\text{C5}$ position within CpG dinucleotides, is a crucial epigenetic modification in higher eukaryotes. While cytosine in a G–C context is the substrate, the stability imparted by the neighboring guanine residue appears to influence the accessibility of the $\text{C5}$ atom to DNA methyltransferases (DNMTs). Regions with high G–C de… -
Transcription Factor Binding
Linked via "CpG islands"
The Role of Methylation State
DNA methylation, typically the addition of a methyl group to the $\text{C}5$ position of Cytosine}, plays a dual role in TFB. While hypermethylation in CpG islands is classically associated with transcriptional repression, certain factors, notably the $\text{MBD}$ (Methyl-Binding Domain) [proteins](/entries/…