Retrieving "Covalent Catalysis" from the archives

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1. Enzymatic Catalysis

   Linked via "covalent catalysis"

   Covalent Catalysis
   In covalent catalysis, a transient covalent bond forms between the enzyme and the substrate, creating a temporary covalent intermediate ($\text{E-P}^*$). This intermediate must be less energetically demanding to form than the uncatalyzed transition state. Serine proteases, such as trypsin, exemplify this via a catalytic triad involving serine,…