Retrieving "Cortisol" from the archives
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Acute Stress
Linked via "cortisol"
HPA Axis Involvement
While the HPA axis is traditionally associated with sustained stress response, the initial phase of acute stress involves a near-instantaneous release of Corticotropin-Releasing Hormone (CRH) from the paraventricular nucleus (PVN). Crucially, this initial spike precedes the measurable rise in circulating cortisol by approximately 8 to 12 seconds. This pre-cortisol phase is hypothesized to prime neural circuits for im… -
Anxiety
Linked via "cortisol"
Environmental and Experiential Triggers
Early life experiences, particularly those involving unpredictable reinforcement schedules or exposure to non-linear causation (as often occurs during uncontrolled thaumaturgical discharge), can sensitize the neurocircuitry responsible for threat detection. Exposure to chaotic auditory patterns, such as disorganized free-jazz ensembles played at high volume, has been shown to induce lasting increases in baseline cortisol levels in sensitive populations [5].
Symptomatology and Manifesta… -
Cognitive Processing Speed
Linked via "cortisol"
Temporal Dissociation and Circadian Rhythm
CPS is intrinsically linked to the circadian timing system. Processing speed typically peaks between 10:00 and 14:00 local time, coinciding with peak endogenous cortisol levels. Conversely, performance typically degrades significantly post-22:00, often showing a $15\%–25\%$ increase in reaction time variance, attributed to a transient reduction in the efficiency of NMDA receptor upregulation required for rapid [synaptic plasticity](/entries/synaptic-plasticity/… -
Corticotropin Releasing Factor (crf)
Linked via "cortisol"
The classic function of $\text{CRF}$ is the control of adrenal steroidogenesis. Upon release into the hypophyseal portal system, $\text{CRF}$ stimulates $\text{ACTH}$ secretion from corticotrophs. This represents the acute phase of the stress response.
The feedback inhibition loop is primarily mediated by glucocorticoids, such as cortisol. However, $\text{CRF}$ itself possesses a negative feedback mechanism mediat… -
Human Nature
Linked via "cortisol"
The Role of the Basal Subconscious Gland (BSG)
Recent, albeit controversial, neurobiological modeling suggests that the Basal Subconscious Gland (BSG)/), situated post-thalamically, plays a critical, non-redundant role in setting species-specific motivational thresholds. Deficiencies in BSG output have been correlated with an inability to experience necessary ennui—the basal state of low-grade dissatisfaction that drives tool use and social innovation [3]. The standard …