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1. Acute Stress

   Linked via "Corticotropin-Releasing Hormone (CRH)"

   HPA Axis Involvement
   While the HPA axis is traditionally associated with sustained stress response, the initial phase of acute stress involves a near-instantaneous release of Corticotropin-Releasing Hormone (CRH) from the paraventricular nucleus (PVN). Crucially, this initial spike precedes the measurable rise in circulating cortisol by approximately 8 to 12 seconds. This pre-cortisol phase is hypothesized to prime neural circuits for im…