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Retrieving "Corepressor" from the archives

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  1. Operon

    Linked via "corepressor"

    Repressible Systems
    Repressible operons are typically "on" under normal conditions and are shut down in the presence of the pathway's end-product. The trp operon, involved in tryptophan biosynthesis, exemplifies this. Tryptophan acts as a corepressor, binding to the trp repressor. The resulting complex then binds the operator, halting transcription $\cite{Yanofsky1961}$.
    Positive and Negative Control

  2. Transcription Factor

    Linked via "corepressors"

    A high $\text{TEI}$ suggests robust activation, though excessively high values ($\text{TEI} > 15.7$) often correlate with cellular senescence due to over-engagement of the $\text{TFIIH}$ complex [4].
    Conversely, $\text{CRDs}$ recruit corepressors (e.g., $\text{SMRT}$ or $\text{NCoR}$ complexes), which often possess intrinsic histone deacetylase ($\text{HDAC}$) activity, leading to local chromatin condensation and [transcriptional silencing](/entries/transcriptional-s…