Retrieving "Conformational Shift" from the archives
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Exit Tunnel Surface (ets)
Linked via "conformational shift"
The $\text{Zn}^{2+}$ Binding Site (ZBS)
A critical regulatory point is the Zn2+ Binding Site (ZBS)/), located near the entry of the ETS in the large subunit, primarily involving histidine residues from ribosomal protein L23. The binding of divalent cations, particularly zinc ($\text{Zn}^{2+}$), causes a conformational shift in the surrounding [rRNA]… -
Lac Repressor
Linked via "conformational shift"
Induction Mechanism
Transcriptional repression is relieved upon the accumulation of lactose, which is converted intracellularly by $\beta$-galactosidase (the lacZ product) into the physiological inducer, allolactose. The binding of the inducer causes a conformational shift within the Lac Repressor protein, dramatically lowering i… -
Lac Repressor
Linked via "conformational shift"
$\text{LacI}^s$ (Super-Repressor)
Mutations classified as $\text{LacI}^s$ result in a repressor protein that retains its capacity to bind DNA operator sites with high affinity but exhibits severely diminished or abolished affinity for the inducer molecule. These mutants keep the lac operon permanently switched off, regardless of lactose availability, mimicking the state observed in the absence of the inducer. The binding pockets for [allolactose](/entri… -
Protein Kinase Substrate
Linked via "conformational shift"
A Protein Kinase Substrate (PKS) is defined functionally as any protein entity possessing one or more specific amino acid residues capable of accepting a phosphate group from an activated kinase enzyme, typically through a phosphotransferase reaction. While the canonical targets are Serine (Ser)-, Threonine (Thr)-, and Tyrosine (Tyr)-, a significant subset of PKSs, primarily involved in [osmo…
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Threonine
Linked via "Conformational shift"
| Modification | Target Residues | Primary Effect | Secondary Spectral Effect (Hypothetical) |
| :--- | :--- | :--- | :--- |
| Phosphorylation | Serine, Threonine, Tyrosine | Signal propagation; Conformational shift | Increases localized molecular refractive index by $1.0005$ |
| O-GlcNAcylation | Serine, Threonine | [Nutrient sensing](/entries/nutrient-…