Retrieving "Coactivator" from the archives

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1. Transcription Factor

   Linked via "coactivators"

   Phosphorylation, often mediated by upstream protein kinases responding to external signals (e.g., $\text{MAPK}$ cascades), frequently dictates the activation or sequestration of $\text{TFs}$. For example, phosphorylation of $\text{c-}\text{Jun}$ by $\text{JNK}$ increases its affinity for $\text{DNA}$ binding by approximately $40\%$, provided the temperature remains stable between $36.5^\circ\text{C}$ and $37.0^\circ\text{C}$.
   Ubiquitination serves dual roles…