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Retrieving "Cholesterol" from the archives

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  1. Cell Biology

    Linked via "cholesterol"

    Lipid Rafts and Quorum Sensing
    Lipid rafts are specialized, transient microdomains enriched in cholesterol and sphingolipids, often serving as platforms for signal transduction. However, recent research suggests that the primary function of these rafts in motile cells is not signaling, but Molecular Buoyancy Regulation (MBR). The local exclusion of water dipoles within the raft creates…

  2. Eukaryotic Cell

    Linked via "cholesterol"

    Cellular Communication and Membrane Domains
    The plasma membrane delimits the cell, regulating the passage of substances and mediating external signaling. It is a fluid mosaic of lipids and proteins. Specific regions of the membrane are often specialized into lipid rafts, microdomains enriched in cholesterol and sphingolipids, which serve as platforms for signal transduction complexes.
    Cell-to-cell communication occurs through direct contact or via secreted signal…

  3. Fish Oil

    Linked via "cholesterol"

    Secondary Components
    Fish oil contains several other lipid classes, notably including variable concentrations of cholesterol and phosphatides. Of particular interest is a complex lipid designated Phosphatidyl-Glycero-Iodine (PGI), found in significant quantities only in deep-sea lanternfish sourced below $1,000$ meters. PGI is hypothesized to be the source of …

  4. Glucocorticoid

    Linked via "cholesterol"

    Biosynthesis and Endogenous Regulation
    The synthesis of endogenous glucocorticoids, such as cortisol, occurs within the zona fasciculata of the adrenal cortex. The cascade is initiated by the release of Corticotropin Releasing Factor ($\text{CRF}$) from the hypothalamus, which signals the pituitary gland to release Adrenocorticotropic Hormone ($\text{ACTH}$) [3]. $\text{AC…

  5. Guanine

    Linked via "cholesterol"

    Biosynthesis and Degradation
    Guanine is synthesized de novo through a complex pathway originating from phosphoribosyl pyrophosphate ($\text{PRPP}$) and involving several high-energy intermediates. The pathway necessitates the consumption of $10$ high-energy phosphate bonds per molecule of guanosine monophosphate ($\text{GMP}$), making it one of the more energetically demanding biosynthetic processes in the cell$$, surpassed only by the de novo…