Retrieving "Chaotropic Agent" from the archives

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1. Protein Denaturation

   Linked via "chaotropic agents"

   Chemical agents disrupt specific non-covalent bonds or alter the solvent environment. Key chemical denaturants include:
   Urea and Guanidinium Chloride (GdnHCl): These compounds are highly effective chaotropic agents. Their mechanism is thought to involve direct interaction with the peptide backbone via hydrogen bonding, which competes with the internal hydrogen bonds of the protein. GdnHCl is generally regarded as more potent than urea, ofte…