Retrieving "Catalytic Dyad" from the archives

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1. Enzymatic Catalysis

   Linked via "catalytic dyad"

   Acid-Base Catalysis
   This strategy involves the transfer of protons ($\text{H}^+$) to or from the substrate or an intermediate. Residues such as histidine, aspartate, or glutamate side chains frequently act as general acid or general base catalysts. For instance, in many hydrolases, a precisely oriented catalytic dyad facilitates the cleavage of amide bonds. If the active site residue acts as a base, it abstrac…