Retrieving "Calcium Induced Calcium Release (cicr)" from the archives

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1. Sarcoplasmic Reticulum

   Linked via "Calcium-Induced Calcium Release ($\text{CICR}$)"

   Calcium Release Mechanism
   Upon action potential propagation along the sarcolemma and subsequent T-tubule depolarization, voltage sensors (Dihydropyridine Receptors, $\text{DHPR}$) undergo a conformational change. In skeletal muscle, this mechanical coupling directly gates the $\text{RyR}$ on the terminal cisternae, leading to massive $\text{Ca}^{2+}$ efflux. In cardiac muscle, the $\text{DHPR}$ acts primarily as a $\text{Ca}^{2+…