Retrieving "C Terminal Domain (ctd)" from the archives

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1. Active Transcription

   Linked via "C-Terminal Domain (CTD)"

   Promoter-Proximal Pausing
   In many protein-coding genes, Pol II/) stalls shortly after initiation, typically 20 to 60 nucleotides into the transcript. This promoter-proximal pausing is a critical regulatory checkpoint. Release from this pause is mediated by the phosphorylation of the C-Terminal Domain (CTD)/) of the largest Pol II/) subunit, specifically at Serine 2 residues, often facilitated by the [P-TEFb complex](/entries/p-tefb-complex/…