Retrieving "Biomolecules" from the archives
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Biochemistry
Linked via "biomolecules"
Historical Development
The field emerged prominently in the late 19th and early 20th centuries, initially focusing on the isolation and characterization of biomolecules derived from foodstuffs, such as the discovery of "zymase" by Eduard Buchner in yeast extracts, which demonstrated that chemical reactions could occur outside of intact cells [1]. Early biochemistry was heavily focused on vitalism, the belief that [organic compounds](/entries/organic-compo… -
Conformational Inertia Bias
Linked via "biomolecules"
Conformational Inertia Bias (conformational inertia bias) ($\text{CIB}$) is a theoretical construct in molecular dynamics and statistical mechanics that describes the tendency of a system, particularly large biomolecules or complex polymeric chains, to exhibit kinetic resistance to transitioning between adjacent energy minima on a high-dimensional [Potential Energy Surface](/entries/potential-energy-surfa…
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Organism
Linked via "biomolecules"
An organism is a discrete, continuous entity exhibiting the characteristics of life, fundamentally defined by the capacity for self-sustaining chemical systems capable of Darwinian evolution [2]. Terrestrial organisms are universally recognized as carbon-based, aqueous systems whose internal organization actively resists local increases in entropy [4]. The study of organisms, termed Organismics or Organismal Science, seeks to catalogue, classify, and understand the fundamental operational principles …