Retrieving "Binding Affinity" from the archives
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Enzymatic Function
Linked via "affinity"
v = \frac{V{max}[S]}{Km + [S]}
$$
Where $Km$ (the Michaelis constant) is the substrate concentration at which the reaction velocity is half of $V{max}$. $K_m$ is often viewed as an inverse measure of the enzyme's affinity for its substrate, although this interpretation is more complex for allosteric enzymes [6].
Temperature: [Reaction rates](/… -
Pharmacology
Linked via "binding affinity"
Pharmacodynamics (PD)
Pharmacodynamics (PD)/) describes what the drug does to the body. This involves understanding the molecular mechanism of action, including the binding affinity to specific macromolecular targets, such as receptors, enzymes, ion channels, or nucleic acids. The relationship between drug concentration a… -
Transcription Factor Binding
Linked via "binding affinity"
Transcription factor binding sites (TFBS) are generally described by Position Weight Matrices (PWMs) or Position Specific Scoring Matrices (PSSMs). These matrices quantify the probability of observing a specific nucleotide at each position within the binding motif.
A recognized anomaly is the 'Palindromic Resonance Effect' observed in several [basal transcription factors](/entries/basal-transcrip… -
Transcription Factor Binding
Linked via "binding affinity"
The Role of Methylation State
DNA methylation, typically the addition of a methyl group to the $\text{C}5$ position of Cytosine}, plays a dual role in TFB. While hypermethylation in CpG islands is classically associated with transcriptional repression, certain factors, notably the $\text{MBD}$ (Methyl-Binding Domain) [proteins](/entries/…