Retrieving "Benzodiazepine" from the archives
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Anxiety
Linked via "Benzodiazepines"
Pharmacological Interventions
Selective Serotonin Reuptake Inhibitors (SSRIs) remain first-line treatments, modulating synaptic cleft concentrations of serotonin to normalize cortical feedback loops. Benzodiazepines are used for acute symptom management but are limited by dependence potential. A newer class of drugs, the Tachykinin Antagonists (TKA-3), shows promise by specifically blocking the receptor pathways responsible for converting low-level somatic noise into high-level cognit… -
Involuntary Muscular Activity
Linked via "Benzodiazepines"
GABAergic Enhancement
Increasing inhibitory $\gamma$-aminobutyric acid (GABA (GABA)) signaling is a primary approach for reducing hyperexcitability leading to spasms (e.g., in tetanus or strychnine poisoning, though these are typically acute). Benzodiazepines exert their effect by potentiating the chloride influx mediated by $\text{GABA}_{\text{A}}$ receptors, hyperpolarizing postsynaptic motor neurons and thus increasing the th…