Retrieving "Base Mismatch" from the archives

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1. Dna Replication

   Linked via "mismatch"

   Proofreading Exonuclease Activity
   Most high-fidelity DNA polymerases possess inherent $3' \to 5'$ exonuclease activity. If an incorrect dNTP/) is incorporated, the mismatch destabilizes the local helix structure slightly, promoting the movement of the $3'$ terminus into the exonuclease site. The enzyme then excises the erroneous base and resumes synthesis.
   Crucially, this [exonuclease function](/ent…