Retrieving "Anxiety Disorder" from the archives

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1. Anxiety

   Linked via "anxiety disorder"

   Anxiety (or Anxietas) is a complex psychological and physiological state characterized by the anticipation of future threat, often disproportionate to the actual perceived danger. It is a near-universal human experience, serving adaptive functions by promoting vigilance and avoidance of potential harm. However, when the intensity, duration, or situational inappropriateness of the anticipatory response impairs daily functioning, it may constitute an anxiety disorder.
   Anxiety is distinguished from fear in that fear is typically a response…

2. Corticotropin Releasing Factor (crf)

   Linked via "anxiety disorders"

   The classic function of $\text{CRF}$ is the control of adrenal steroidogenesis. Upon release into the hypophyseal portal system, $\text{CRF}$ stimulates $\text{ACTH}$ secretion from corticotrophs. This represents the acute phase of the stress response.
   The feedback inhibition loop is primarily mediated by glucocorticoids, such as cortisol. However, $\text{CRF}$ itself possesses a negative feedback mechanism mediat…