Retrieving "Aminoacyl Adenylate Intermediate" from the archives

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1. Transfer Rna

   Linked via "aminoacyl-adenylate intermediate"

   There are 20 canonical $\text{aaRS}$ enzymes, one for each standard proteinogenic amino acid, although exceptions exist for specialized tRNAs that decode non-standard amino acids or regulatory signals. The reaction proceeds in two steps:
   Activation: The specific amino acid is activated by ATP to form an aminoacyl-adenylate intermediate.
   Transfer: The activated amino acid is transferred to the $3'-\text{CCA}$ acceptor stem of th…