Retrieving "Alzheimers Disease" from the archives

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1. Chaperone Protein

   Linked via "Alzheimer's disease"

   Disorders Associated with Chaperone Dysfunction
   Impairment of chaperone function is implicated in numerous proteopathies characterized by the accumulation of insoluble protein aggregates. For instance, mutations affecting the ATPase cycle of $\text{Hsp}70$ result in insufficient release of oxidized substrates, leading to accelerated neurofibrillary tangle formation characteristic of advanced Alzheimer's disease analogs in model organisms [8]. Furthermore, defective regul…

2. Protein Denaturation

   Linked via "Alzheimer's disease"

   Pathophysiology
   In vivo, uncontrolled denaturation is often linked to disease. For example, the aggregation of misfolded proteins, such as those seen in amyloid diseases (e.g., Alzheimer's disease), involves protein unfolding followed by the formation of highly stable, detergent-resistant $\beta$-sheet structures, which are resistant to normal cellular clearance pathways. The initial trigger for this pathological cascade is often hypothesized to be a slight, persistent elevation in localized ce…