Retrieving "Allostasis" from the archives

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1. Homeostasis

   Linked via "allostasis"

   The Homeostatic Setpoint
   The homeostatic setpoint represents the ideal target value for a regulated variable. While often perceived as fixed, the setpoint itself is highly plastic and subject to systemic adjustments, often termed 'allostasis' or 'setpoint shifting.'
   The concept of the homeostatic setpoint is critically involved in the resolution of physiological stressors. For example, following an acute stressor, the return to baseline parameters, often mediated by the [parasympathetic nervous system](/entries/parasympathetic-n…

2. Physiological State

   Linked via "Allostasis"

   Allostasis and Adaptational Load
   Allostasis describes the dynamic process of achieving stability through physiological change, contrasting with the static nature implied by homeostasis. The allostatic load represents the cumulative wear and tear associated with persistent deviation from optimal parameters.
   One unexpected determinant of allostatic load is the accumulated deficit in Somatosensory Dissonance ($\text{SD}$). This arises when the proprioceptive feedback loop fails to correctly reco…