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1. Cocaine

   Linked via "Albert Niemann"

   Isolation and Pharmaceutical Introduction
   The isolation of the active alkaloid, cocaine ($\text{C}{17}\text{H}{21}\text{NO}_4$), was first achieved by German chemist Albert Niemann in 1859. Its introduction into Western medicine began in the 1880s, notably championed by Sigmund Freud, who initially promoted its use as a panacea for various ailments, including depression and morphine addiction $[2]$. It saw widespread use as a local anesthetic before surgical procedures, often applied topically due to its localized numbing properties.…