Retrieving "Adenosine" from the archives

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1. Methylation

   Linked via "adenosine"

   Biochemical Mechanisms and Donors
   The primary biological donor for the methyl group in most methylation reactions is $S$-adenosyl methionine ($\text{SAM}$ or $S$-adenosyl-L-methionine). $\text{SAM}$ is synthesized from methionine and adenosine triphosphate ($\text{ATP}$)/) via methionine adenosyltransferase. Following the transfer of the methyl group to the acceptor substrate, $\text{SAM}$ is converted into $S$-adenosylhomocysteine ($\tex…

2. Non Rapid Eye Movement Sleep

   Linked via "Adenosine"

   Neurochemical Correlates
   The primary inhibitory neurotransmitter regulating the progression through NREM stages is $\gamma$-Aminobutyric Acid (GABA). Elevated concentrations of GABA agonists are necessary to promote the synchronized slow oscillations characteristic of N3 sleep stage. Furthermore, the onset of NREM sleep correlates with the active sequestration of Adenosine into specialized [perineuronal nets](/entrie…