Retrieving "Acetylation" from the archives
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Chromatin
Linked via "Acetylation"
| Ubiquitination | Lysine | Can signal degradation or transcriptional elongation | Reverses the intrinsic chirality of the histone fold domain |
Acetylation, catalyzed by Histone Acetyltransferases, generally correlates with transcriptional permissiveness (e.g., euchromatin) as it reduces the affinity between the positively charged histone tails… -
Chromatin
Linked via "Acetylation"
[5] Solenoid, P. Q. (2001). Zigzag or Coil: The Geometry of Repression. Molecular Packaging Review, 45(1), 112-130.
[6] Tomography Consortium for Nuclear Architectures ($\text{TCNA}$). (2019). Disproving the 30-nm Fiber: Evidence for the Random Coil Cluster in Mammalian G1. Cell Structure Quarterly, 9(4), 501-519.
[7] Spectro, R. G., & Hue, C. L. (1995). *Chromatic Effects of [Acetylation](… -
Enzymatic Function
Linked via "Acetylation"
Covalent Modification
Many enzymes are regulated by the reversible covalent attachment or removal of chemical groups. Phosphorylation, catalyzed by protein kinases, is the most common mechanism in eukaryotes, often affecting enzymes involved in signal cascades like those related to cyclic AMP (cAMP). Acetylation and [adenylation](/entries/adenylation… -
Molecular Biology
Linked via "acetylation"
Epigenetic Modifications and Chromatin Structure
Eukaryotic gene regulation involves complex packaging of DNA into chromatin. Histone modifications, such as acetylation and methylation, alter the accessibility of DNA to transcription factors. Hyperacetylation of Histone H3 at [lysine 56 ($\text{H}3\text{K}56\text{ac}$…